NIHR - Leeds Musculoskeletal Biomedical Research Unit (LMBRU)

Our
people

Dr Xuebin Yang

Title

Head of Tissue Engineering Research

Email

X.B.Yang@leeds.ac.uk

Phone

01133436162

Address

Biomaterials and Tissue Engineering Group
Department of Oral Biology
Leeds Dental Institute
University of Leeds
Worsley Building, Clarendon Way
Leeds LS2 9LU, United Kingdom

LMBRU Role

LMBRU Member

Research Interests

Stem cell therapy, skeletal tissue engineering (bone, cartilage, osteochondral, dentine, ligament)

Significant Publications

Journals

  • Sushmita Saha, Jennifer Kirkham, David Wood, Stephen Curran, and Xuebin B. Yang. The proliferative and chondrogenic potential of human bone marrow stromal cells, neonatal and adult chondrocytes. Tissue Engineering and Regenerative Medicine. Online March 2012.
  • Cassilda Cunha-Reis, Alicia J. El Haj, Xuebin B Yang and Ying Yang. Illuminating Biomaterials for Surgical Repair – Real-time Monitoring of Implant Degradation in vivo. Tissue Engineering and Regenerative Medicine. Online November 2011.
  • JI Dawson, JM Kanczler, XB Yang, GS Attard, RO Oreffo. Clay Gels For the Delivery of Regenerative Microenvironments. Adv Mater. 2;23(29):3304-8. ( 2011).
  • E Jones, X Yang. Mesenchymal stem cells and bone regeneration: Current status. Injury. Jun;42(6):562-8. (2011)
  • PJ Newby, R El-Gendy, J Kirkham, XB Yang, ID Thompson, AR Boccaccini.  Ag-doped 45S5 Bioglass (R)-based bone scaffolds by molten salt ion exchange: processing and characterization. J Mater SCI-Mater M 22(3):557-569. (2011).
  • S. Saha, J. Kirkham, D. Wood, S. Curran & X.B. Yang. The proliferative and chondrogenic potential of human bone marrow stromal cells, neonatal and adult chondrocytes. BBRC, 401(3):333-8. (2010)
  • E.A. Horner, J. Kirkham, D. Wood, S. Curran, M. Smith, B. Thomson, and X.B. Yang. Appendicular Bone Defect Models for Tissue Engineering Applications: Criteria for Choice. Tissue Engineering Part B: Reviews. 16(2): 263-271 (2010).
  • A.T. Harris, M. Garg, X.B. Yang, S.E. Fisher, J. Kirkham, D.A. Smith, D.P. Martin-Hirsch and A.S. High. Raman spectroscopy and advanced mathematical modelling in the discrimination of human thyroid cell lines. Head & Neck Oncology 1:38 (2009).
  •  D.-L. Li, X. Liu, R. Xia, C. Ross, X.B. Yang, Lin-Hua Jiang. Pharmacological properties of ATP-sensitive purinergic receptors expressed in human G292 osteoblastic cells. European Journal of Pharmacology. 617(1-3):12-16 (2009)
  •  A.T Harris, A. Lungari, C.J Needham, S.L. Smith, M.A. Lones, N. Cooper, S.E. Fisher, X.B. Yang, A.S. High, J. Kirkham and A.D.M. Smith. Potential for Raman Spectroscopy to Provide Cancer Screening using a Peripheral Blood Sample. Head & Neck Oncology. 1:34 (2009).
  • H.W. Tang, X.B. Yang, J. Kirkham, and D. A. Smith. Chemical probing of single cancer cells with gold nanoaggregates by surface-enhanced raman scattering.  Applied Spectroscopy. 62(10):1060-1069 (2008).
  • H.W. Tang, X.B. Yang, J. Kirkham and D.A. Smith. Probing Intrinsic and Extrinsic Components in Single Osteosarcoma Cells by Near-infrared Surface Enhanced Raman Scattering. Analytical Chemistry. 79, 3646-3653 (2007).
  • +M.M.C.G. Silva, L.A. Cyster, J.J.A. Barry, X.B. Yang, R.O.C. Oreffo, D.M. Grant, C.A. Scotchford, S.M. Howdle, K.M. Shakesheff and F.R.A.J. Rose. Anisotropic architecture enhances cell and tissue infiltration into tissue engineering scaffolds. Biomaterials. 27(35):5909-5917 (2006).
  • A. Firth, A. Aggeli, J. Burke, X.B. Yang and J. Kirkham. Biomimetic Self-Assembling Peptide Scaffolds for Hard Tissue Engineering. Nanomedicine. 1(2):189-199 (2006).
  • Y Xu, SH Mirmalek-Sani, X Yang, J Zhang and RO Oreffo. The use of small interfering RNAs to inhibit adipocyte differentiation in human preadipocytes and fetal-femur-derived mesenchymal cells. Exp Cell Res. 312(10):1856-64 (2006).
  • X.B. Yang, D. Webb, J. Blaker, A.R. Boccaccini, V. Maquet, C. Cooper and R.O. Oreffo. Evaluation of human bone marrow stromal cell growth on biodegradable polymer/bioglass composites. Biochem Biophys Res Commun. 21;342(4):1098-107 (2006).
  • E.A. Jones, I. Pountos, X.B. Yang and D. Mcgonagle. Mesenchymal stem cell and their future for osteoporotic fracture repair.  Advances in Osteoporotic Fracture Management. 4(3):11-16 (2006).
  • E.A. Jones and X.B. Yang. Mesenchymal Stem Cells and their Future in Bone Repair International Journal of Advances in Rheumatology. 3(3):15-21 (2005). (Leading article)
  • D.W. Green, I. Leveque, D. Walsh, D. Howard, X.B. Yang, K. Partridge, S. Mann, and R.O.C. Oreffo. Biomineralized polysaccharide capsules for encapsulation, organization, and delivery of human cell types and growth factors. Advanced Functional Materials. 15:917-923 (2005).
  • D. Green, D. Walsh, X.B. Yang, S. Mann and R.O.C. Oreffo. Stimulation of human bone marrow stromal cells using growth factor encapsulated calcium carbonate porous microspheres. Journal of Materials Chemistry. 14:2206-2212 (2004).
  • X.B. Yang, R.S. Bhatnagar, S. Li and R.O.C. Oreffo. Collagen biomimetic scaffolds for bone tissue engineering. Tissue Engineering. 10(7-8):1148-59  (2004).
  • X.B. Yang, M.J. Whitaker?W. Sebald, N.M.P. Clarke, S.M. Howdle, K.M. Shakesheff and R.O.C. Oreffo. Human osteoprogenitor bone formation using encapsulated bone morphogenetic protein 2 in porous polymer scaffolds. Tissue Engineering. 10(7-8):1137-45 (2004).
  • D. Green, D. Haward, X.B. Yang, M. Kelly and R.O.C. Oreffo. Natural marine sponge fibre skeleton: a biomimetic scaffold for human osteoprogenitor cell attachment, growth and differentiation. Tissue Engineering. 9(6):1159-66 (2003).
  • A.K. Salem, F.R.A.J. Rose, R.O.C. Oreffo, X.B. Yang, M.C. Davies, J.R. Mitchell, C.J. Roberts, S. Stolnik-Trenkic, S.J.B. Tendler, P.M. Williams and K.M. Shakesheff. Porous Polymer and Cell Composites that Self-Assemble in Situ. Advanced Materials15(3):210-213 (2003). (This paper has been highlighted in Nature Materials in the 13th March 2003:  Scaffold delivered through a needle).
  • X.B. Yang, D.W. Green, H.I. Roach, N.M.P. Clarke, H.C. Anderson, S.M. Howdle, K.M. Shakesheff, and R.O.C. Oreffo. Novel osteoinductive biomimetic scaffolds stimulate human osteoprogenitor activity – Implications for skeletal repair. Connective Tissue Research. 44(Suppl. 1):312-317 (2003).
  • X.B. Yang, R.Tare, K.A. Partridge, H.I. Roach, N.M.P. Clarke, S.M. Howdle, K.M. Shakesheff, and R.O.C. Oreffo. Induction of human osteoprogenitor chemotaxis, proliferation, differentiation, and bone formation by osteoblast stimulating factor-1/pleiotropin: osteoconductive biomimetic scaffolds for tissue engineering. Journal of Bone and Mineral Research. 18(1):47-57 (2003).
  • D. Howard, K. Partridge, X.B. Yang, N.M.P. Clarke, Y. Okubo, K. Bessho, S.M. Howdle, K.M. Shakesheff, and R.O.C. Oreffo. Immunoselection and adenoviral genetic modulation of human osteoprogenitors: In vivo bone formation on PLA scaffold. Biochemical and Biophysical Research Communications. 299:208-215  (2002)..
  • K. Partridge*, X.B. Yang*, N.M.P. Clarke, Y. Okubo, K. Bessho, W. Sebald, S.M. Howdle, K.M. Shakesheff, and R.O.C. Oreffo. Adenoviral BMP-2 Gene Transfer in Mesenchymal Stem Cells: In vitro and In vivo Bone Formation on Biodegradable Polymer Scaffolds. Biochemical and Biophysical Research Communications. 292:144–152 (2002). (*Joint first author).

About

Dr Xuebin Yang (XY), the head of tissue engineering research at Leeds Dental Institute, the University of Leeds, UK and Concurrent Professor of School of Medicine, Nanjing University (China); Concurrent Professor of Henan University of Science and Technology (China), Invited Professor of Tokyo Women’s Medical University (Japan). His research profile combines 12 years’ exceptional expertise in clinical orthopaedics and medical devices design (3 patents) with highly specialised research expertises in skeletal tissue engineering using stem cell therapy (US patent 2007), biomimetic biomaterials (UK patent 2004, UK patent 2009 and national phase on 2011) and in vitro, in vivo models. Originally a consultant orthopaedic surgeon (clinical associate professor), XY completed his primary medical education in 1984. Subsequently, he was awarded an MSc degree in hand and microsurgery (1992, Fudan University, China) and a PhD degree in bone tissue engineering (2002, University of Southampton, UK). XY currently lead a team of 10 PhD students and five fellows who are working on stem cell therapy and skeletal tissue engineering in regenerative medicine and dentistry using stem cell therapy, biomimetic biomaterials and in vitro/in vivo models. He is on the ‘Medical Research Council Stem Cell User Liaison Committee’, BBSRC peer review committee and the strategic consultants of BITE CIC and Tissue Science Lab plc. He is also the treasurer of the British Orthopaedic Research Society and a committee member of the Yorkshire Biomaterial & Tissue Engineering Group, EPSRC Doctoral Training Centre and The Wellcome EPSRC Leeds Medical Engineering Centre (WELMEC). He is also a regular referee for research councils and other funding bodies (UK, USA, Canada and China). XY is the regular reviewers of related journals in the field.

Collaboration

Academics:

Dr Genever (York), Prof. Dalgarno (Newcastle), Dr  Telford (Bradford), Prof. Oreffo (Southampton), Prof. Shakesheff (Nottingham), Prof. Attard (Southampton), Dr Yang (Keele), Dr Su (Bristol), Prof Mantalaris (Imperial College), Prof Boccaccini (Imperial College), Dr Huang (Kings College), Prof Jones (Kings College), Prof Li and Dr Wan (Hong Kong), Professor Li (UCB, USA), Professor Bhatnagar (UCSF, USA), Prof Li (WFU, USA), Professor Hu (NU, China), Prof Tang (WU, China), Prof Feng (HUST, China), Professor Sun (NU, China) and Professor Jin (Xian, China), Prof Okano (Tokyo, Japan), Prof Akashi (Osaka, Japan), Prof Cornish (Auckland, New Zealand), Dr Ang (Perth, Australia).


Industries:

Smith & Nephew (UK), CeraPedics (USA), Densply Ltd (USA), Geistlich (Switzerland), Oraldent (UK), BITE CIC (UK), Xiros (UK), RegenTec (UK), Noetherix Ltd (York), KangHui (China).

Grants Awarded

2011

The Royal Society: international exchange scheme

£12k

2011

UK-China Science Bridge Award

£50k

2011

IKC Funding

£50k

2010

UK-China Science Bridge Award

£44k

2009

Characterisation and Further Development of a Novel Tissue Scaffold Vehicle for the delivery of Regenerative and Antibacterial Strategies. (N8)

£62k


2009

Development of an novel osteochondral implant (N8)

£50k


2009

Wellcome Trust ViP award

£20k


2009

Wellcome Trust-EPSRC-Leeds Medical Engineering Centre (“WELMEC”)

£300k (Co-I)


2009

Autogenic stem cell therapy (Industrial gift funding)

$30k

Related Links

http://www.dentistry.leeds.ac.uk/staffpages/Xuebin%20Yang/default.aspx

http://www.leeds.ac.uk/dental/research/tissue_engineering.html